the association of pnpla3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat协会pnpla3变异与肝酶在儿童肥胖与腹部脂肪是由交互.pdfVIP

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the association of pnpla3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat协会pnpla3变异与肝酶在儿童肥胖与腹部脂肪是由交互.pdf

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the association of pnpla3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat协会pnpla3变异与肝酶在儿童肥胖与腹部脂肪是由交互

The Association of PNPLA3 Variants with Liver Enzymes in Childhood Obesity Is Driven by the Interaction with Abdominal Fat 1 1 1 2 1 Emanuele Miraglia del Giudice *, Anna Grandone , Grazia Cirillo , Nicola Santoro , Alessandra Amato , 1 1 1 1 Carmine Brienza , Piera Savarese , Pierluigi Marzuillo , Laura Perrone ` 1 Department of Pediatrics, Seconda Universita degli Studi di Napoli, Napoli, Italy, 2 Department of Pediatrics, Yale University School of Medicine, New Haven, Conneticut, United States of America Abstract Background and Aims: A polymorphism in adiponutrin/patatin-like phospholipase-3 gene (PNPLA3), rs738409 C-.G, encoding for the I148M variant, is the strongest genetic determinant of liver fat and ALT levels in adulthood and childhood obesity. Aims of this study were i) to analyse in a large group of obese children the role of the interaction of not-genetic factors such as BMI, waist circumference (W/Hr) and insulin resistance (HOMA-IR) in exposing the association between the I148M polymorphism and ALT levels and ii) to stratify the individual risk of these children to have liver injury on the basis of this gene-environment interaction. Methods: 1048 Italian obese children were investigated. Anthropometric, clinical and metabolic data were collected and the PNPLA3 I148M variant genotyped. Results: Children carrying the 148M allele showed higher ALT and AST levels (p = 0.000006 and p = 0.0002, respectively). Relationships between BMI-SDS, HOMA-IR and W/Hr with ALT were analysed in function of the different PNPLA3 genotypes. Children 148M h