the chemical components of sesbania grandiflora root and their antituberculosis activity田菁大花蔷薇根的化学成分及其对公开活动.pdfVIP

Pharmaceuticals 2012, 5, 882-889; doi:10.3390/ph5080882 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Article The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity Noviany Hasan 1,2, Hasnah Osman 1,*, Suriyati Mohamad 3, Wong Keng Chong 1, 4 3 Khalijah Awang and Anis Safirah Mohd Zahariluddin 1 School of Chemical Sciences, University of Science Malaysia, Minden 11800, Penang, Malaysia; E-Mails: novyany73@ (N.H.); kcwong@usm.my (W.K.C.) 2 Department of Chemistry, University of Lampung, Bandar Lampung 35145, Lampung, Indonesia 3 School of Biological Sciences, University of Science Malaysia, Minden 11800, Penang, Malaysia; E-Mails: suri@usm.my (S.M.); anissafirah@ (A.S.M.Z.) 4 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mail: khalijah@.my (K.A) * Author to whom correspondence should be addressed; E-Mail: ohasnah@usm.my; Tel.: +604-653-3558; Fax: +604-657-4854. Received: 2 July 2012; in revised form: 24 July 2012 / Accepted: 3 August 2012 / Published: 23 August 2012 Abstract: Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora . The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1–