原创力文档the chemerinchemr23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivochemerinchemr23系统不影响老鼠和人类巨噬细胞体外的炎性反应.pdfVIP
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the chemerinchemr23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivochemerinchemr23系统不影响老鼠和人类巨噬细胞体外的炎性反应
The Chemerin/ChemR23 System Does Not Affect the Pro-
Inflammatory Response of Mouse and Human
Macrophages Ex Vivo
1,3. 1. 1,2 1 ¨ 1
Benjamin Bondue , Olivier De Henau , Souphalone Luangsay , Thalie Devosse , Patricia de Nadaı ,
1 1 1
Jean-Yves Springael , Marc Parmentier *, Olivier Vosters
´ ´ ´ ´
1 Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire (I.R.I.B.H.M.), Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium,
ˆ ´
2 Euroscreen SA, Brussels, Belgium, 3 Service de Pneumologie, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
Abstract
Macrophages constitute a major component of innate immunity and play an essential role in defense mechanisms against
external aggressions and in inflammatory responses. Chemerin, a chemoattractant protein, is generated in inflammatory
conditions, and recruits cells expressing the G protein-coupled receptor ChemR23, including macrophages. Chemerin was
initially expected to behave as a pro-inflammatory agent. However, recent data described more complex activities that are
either pro- or anti-inflammatory, according to the disease model investigated. In the present study, peritoneal macrophages
were generated from WT or ChemR23 2/ 2 mice, stimulated with lipopolyssaccharide in combination or not with IFN-c and
the production of pro- (TNF-
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