原创力文档the criteria to confirm the role of epstein-barr virus in nasopharyngeal carcinoma initiation标准确认巴尔病毒在鼻咽癌启蒙的作用.pdfVIP
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the criteria to confirm the role of epstein-barr virus in nasopharyngeal carcinoma initiation标准确认巴尔病毒在鼻咽癌启蒙的作用
Int. J. Mol. Sci. 2012, 13, 13737-13747; doi:10.3390/ijms131013737
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
The Criteria to Confirm the Role of Epstein-Barr Virus in
Nasopharyngeal Carcinoma Initiation
Ai-Di Gu 1,2, Mu-Sheng Zeng 1 and Chao-Nan Qian 1,3,*
1 State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center,
651 Dongfeng East Road, Guangzhou 510060, China; E-Mails: topgad@ (A.-D.G.);
zengmsh@ (M.-S.Z.)
2 Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology,
University of North Carolina, Chapel Hill, NC 27599, USA
3 Laboratory of Cancer and Developmental Cell Biology, Van Andel Research Institute,
333 Bostwick Ave. NE, Grand Rapids, MI 49503, USA
* Author to whom correspondence should be addressed; E-Mail: qianchn@;
Tel.: +86-20 Fax: +86-20
Received: 5 September 2012; in revised form: 16 October 2012 / Accepted: 17 October 2012 /
Published: 23 October 2012
Abstract: Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC),
but it remains obscure whether EBV is a viral cause of, or only an accompaniment of,
NPC. We will discuss the accumulated evidence pointing to the relationship between EBV
infection and NPC initiation from epidemiologic, pathogenic, molecular oncogenic, and
experimental animal studies. We believe that convincing evidence from these perspecti
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