原创力文档the creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway不同的羟基化模式的创建和生理相关性类黄酮途径.pdfVIP
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the creation and physiological relevance of divergent hydroxylation patterns in the flavonoid pathway不同的羟基化模式的创建和生理相关性类黄酮途径
Int. J. Mol. Sci. 2010, 11, 595-621; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
The Creation and Physiological Relevance of Divergent
Hydroxylation Patterns in the Flavonoid Pathway
Heidi Halbwirth
Institut für Verfahrenstechnik, Umwelttechnik und Technische Biowissenschaften, Technische
Universität Wien, Getreidemarkt 9/1665, A-1060 Wien, Austria;
E-Mail: hhalb@mail.zserv.tuwien.ac.at; Tel.: +43-1-58801-17311; Fax: +43-1-58801-17399
Received: 11 December 2009; in revised form: 27 January 2010 / Accepted: 28 January 2010 /
Published: 4 February 2010
Abstract: Flavonoids and biochemically-related chalcones are important secondary
metabolites, which are ubiquitously present in plants and therefore also in human food.
They fulfill a broad range of physiological functions in planta and there are numerous
reports about their physiological relevance for humans. Flavonoids have in common a basic
C -C -C skeleton structure consisting of two aromatic rings (A and B) and a heterocyclic
6 3 6
ring (C) containing one oxygen atom, whereas chalcones, as the intermediates in the
formation of flavonoids, have not yet established the heterocyclic C-ring. Flavonoids are
grouped into eight different classes, according to the oxidative status
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