the dare study of relapse prevention in depression design for a phase 12 translational randomised controlled trial involving mindfulness-based cognitive therapy and supported self monitoring敢抑郁症的复发预防的研究设计阶段12平移随机对照试验包括正念认知疗法和自我监控的支持.pdfVIP

The DARE study of relapse prevention in depression: design for a phase 1/2 translational randomised controlled trial involving mindfulness-based cognitive therapy and supported self monitoring Shawyer et al. Shawyer et al. BMC Psychiatry 2012, 12:3 /1471-244X/12/3 (19 January 2012) Shawyer et al. BMC Psychiatry 2012, 12:3 /1471-244X/12/3 STUDY PROTOCOL Open Access The DARE study of relapse prevention in depression: design for a phase 1/2 translational randomised controlled trial involving mindfulness-based cognitive therapy and supported self monitoring 1 1* 2 3 4 5 Frances Shawyer , Graham N Meadows , Fiona Judd , Paul R Martin , Zindel Segal and Leon Piterman Abstract Background: Depression is a common condition that typically has a relapsing course. Effective interventions targeting relapse have the potential to dramatically reduce the point prevalence of the condition. Mindfulness- based cognitive therapy (MBCT) is a group-based intervention that has shown efficacy in reducing depressive relapse. While trials of MBCT to date have met the core requirements of phase 1 translational research, there is a need now to move to phase 2 translational research - the application of MBCT within real-world settings with a view to informing policy and clinical practice. The aim of this trial is to examine the clinical impact and health economics of MBCT under real-world conditions and where efforts have been made to assess for and prevent resentful demoralization among the control group. Secondary aims of the project involve extending the phase 1 agenda to an examination of the effect