原创力文档the effectiveness of cognitive behavioral therapy on the quality of life of patients with inflammatory bowel disease multi-center design and study protocol (kl!c- study)认知行为疗法的有效性在炎症性肠病的患者的生活质量多中心设计和研究协议(吉隆坡!.pdfVIP
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the effectiveness of cognitive behavioral therapy on the quality of life of patients with inflammatory bowel disease multi-center design and study protocol (kl!c- study)认知行为疗法的有效性在炎症性肠病的患者的生活质量多中心设计和研究协议(吉隆坡!
Bennebroek Evertsz et al. BMC Psychiatry 2012, 12:227
/1471-244X/12/227
STUDY PROTOCOL Open Access
The effectiveness of cognitive behavioral therapy
on the quality of life of patients with
inflammatory bowel disease: multi-center design
and study protocol (KL!C- study)
1* 2 3 4,5 4
Floor Bennebroek Evertsz’ , Claudi LH Bockting , Pieter CF Stokkers , Chris Hinnen , Robbert Sanderman
and Mirjam AG Sprangers1
Abstract
Background: Inflammatory Bowel Disease (IBD) patients report poorer quality of life (QoL) and more anxiety and
depressive symptoms than controls from the general population. Cognitive behavioral therapy (CBT) is effective for
anxiety and depression, but questionable in case of co-morbidity with IBD. Therefore, an adapted new CBT
specifically designed for IBD patients was developed. The objective of this study is to evaluate the effectiveness of
adapted CBT on QoL.
Methods/design: IBD patients with a poor level of mental QoL (score less than or equal to 23 on the mental
health scale of SF-36) will be randomly assigned to the experimental (n = 40) or waiting-list control condition
(n = 40). The experimental condition will then immediately start CBT. The waiting-list control condition will wait
3,5 months before CBT begins with pre- and post assessments. Both conditions will complete a baseline and
follow-up assessment following CBT and a mid-treatment assessment. The primary outcome is IBD-specific QoL
(IBDQ). Secondary outcomes are generic QoL (SF-36) and anxiety and depression complaints (HADS, CES-D).
Additionally, we will examine the working mechanism of the psychological intervention by investigating the impact
of the intervention on illness-related cognitions,
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