the immuno-regulatory effects of schisandra chinensis and its constituents on human monocytic leukemia cells五味子属的immuno-regulatory效应对及其成分对人类单核细胞的白血病细胞.pdfVIP

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the immuno-regulatory effects of schisandra chinensis and its constituents on human monocytic leukemia cells五味子属的immuno-regulatory效应对及其成分对人类单核细胞的白血病细胞.pdf

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the immuno-regulatory effects of schisandra chinensis and its constituents on human monocytic leukemia cells五味子属的immuno-regulatory效应对及其成分对人类单核细胞的白血病细胞

Molecules 2011, 16, 4836-4849; doi:10.3390/molecules OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Immuno-Regulatory Effects of Schisandra chinensis and Its Constituents on Human Monocytic Leukemia Cells Rong-Dih Lin 1,2, Yi-Wen Mao 2,3, Sy-Jye Leu 4, Ching-Yi Huang 2 and Mei-Hsien Lee 2,5,* 1 Department of Internal Medicine, Ho-Ping Branch, Taipei City Hospital, Taipei 100, Taiwan; E-Mail: lrd678@ (R.-D.L.) 2 Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan; E-Mails: cutemaomao2007@ (Y.-W.M.); louies68@.tw (C.-Y.H.) 3 School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan 4 Department of Microbiology and Immunology, Taipei Medical University, Taipei 110, Taiwan; E-Mail: cmbsycl@.tw (S.-J.L.) 5 Center for Reproductive Medicine Sciences, Taipei Medical University Hospital, Taipei 110, Taiwan * Author to whom correspondence should be addressed; E-Mail: lmh@.tw; Tel.: +886 (2) 2736-1661 ext. 6151. Received: 19 April 2011; in revised form: 7 June 2011 / Accepted: 9 June 2011 / Published: 10 June 2011 Abstract : Many diseases occur when the immune system is weakened. Intracellular signals activate immuno-responsive cells to produce cytokines that modulate the immune response. Schisandra chinensis has been used traditionally to treat general fatigue, neurasthenia, and spontaneous sweating. In the present study, the effect of constituents of S. chinensis on cytokine release by human monocytic