the impact of autonomic dysfunction on survival in patients with dementia with lewy bodies and parkinsons disease with dementia自主功能障碍对患者生存的影响与路易体痴呆和帕金森病痴呆.pdfVIP

The Impact of Autonomic Dysfunction on Survival in Patients with Dementia with Lewy Bodies and Parkinson’s Disease with Dementia 1 2,3 1 1 Kajsa Stubendorff *, Dag Aarsland , Lennart Minthon , Elisabet Londos ¨ 1 Clinical Memory Research Unit, Department of Clinical Sciences, Malmo, Lund University, Sweden, 2 Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway, 3 Department of Neurobiology, Ward and Society, Alzheimer’s Disease Research Center, Karolinska Institutet, Stockholm, Sweden Abstract Introduction: Autonomic dysfunction is a well-known feature in neurodegenerative dementias, especially common in a- synucleinopathies like dementia with Lewy bodies and Parkinson’s disease with dementia. The most common symptoms are orthostatic hypotension, incontinence and constipation, but its relevance in clinical practice is poorly understood. There are no earlier studies addressing the influence of autonomic dysfunction on clinical course and survival. The aim of this study was to investigate the frequency of the three most common features of autonomic dysfunction and analyze how it affects survival. Methods: Thirty patients with dementia with Lewy bodies and Parkinson’s disease with dementia were included in this prospective, longitudinal follow-up study. Presence of incontinence and constipation was recorded at baseline. Blood pressure was measured at baseline, after 3 months and after 6 months according to standardized procedures, with 5 measurements during 10 minutes after rising. Orthostatic hypotension was defined using consensus definitions and persistent orthostatic