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the impact of cyp2d6 genotyping on tamoxifen treatment它莫西芬治疗型cyp2d6的影响
Pharmaceuticals 2010, 3, 1122-1138; doi:10.3390/ph3041122
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Impact of CYP2D6 Genotyping on Tamoxifen Treatment
Roberta Ferraldeschi 1,2 and William G. Newman 2,*
1 Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20
4BX, UK; E-Mail: roberta.ferraldeschi@christie.nhs.uk (R.F.)
2 Genetic Medicine, St Marys Hospital, Manchester Academic Health Sciences Centre (MAHSC),
University of Manchester, Oxford Road, Manchester, M13 9WL, UK
* Author to whom correspondence should be addressed; E-Mail: william.newman@manchester.ac.uk;
Tel.: +044-161-276-6264; Fax: +044-161-276-6145.
Received: 30 December 2009; in revised form: 12 March 2010 / Accepted: 9 April 2010 /
Published: 15 April 2010
Abstract: Tamoxifen remains a cornerstone of treatment for patients with oestrogen-
receptor-positive breast cancer. Tamoxifen efficacy depends on the biotransformation,
predominantly via the cytochrome P450 2D6 (CYP2D6) isoform, to the active metabolite
endoxifen. Both genetic and environmental (drug-induced) factors may alter CYP2D6
enzyme activity directly affecting the concentrations of active tamoxifen metabolites.
Several studies suggest that germline genetic variants in CYP2D6 influence the clinical
outcomes of patients treated with adjuvant tamoxifen. Here, we review the existing data
relating CYP2D6 genotypes to tamoxifen efficacy.
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