原创力文档the impact of focused gene ontology curation of specific mammalian systems集中的影响基因本体特定的哺乳动物系统的管理.pdfVIP
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the impact of focused gene ontology curation of specific mammalian systems集中的影响基因本体特定的哺乳动物系统的管理
The Impact of Focused Gene Ontology Curation of
Specific Mammalian Systems
1 1 2 2 1
Yasmin Alam-Faruque , Rachael P. Huntley , Varsha K. Khodiyar , Evelyn B. Camon , Emily C. Dimmer ,
1 1 1 2 3
Tony Sawford , Maria J. Martin , Claire O’Donovan , Philippa J. Talmud , Peter Scambler , Rolf
1 2
Apweiler , Ruth C. Lovering *
1 EMBL-European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom, 2 Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University
College London, London, United Kingdom, 3 Molecular Medicine Unit, Institute of Child Health, University College London, London, United Kingdom
Abstract
The Gene Ontology (GO) resource provides dynamic controlled vocabularies to provide an information-rich resource to aid
in the consistent description of the functional attributes and subcellular locations of gene products from all taxonomic
groups (). System-focused projects, such as the Renal and Cardiovascular GO Annotation Initiatives,
aim to provide detailed GO data for proteins implicated in specific organ development and function. Such projects support
the rapid evaluation of new experimental data and aid in the generation of novel biological insights to help alleviate human
disease. This paper describes the improvement of GO data for renal and cardiovascular research communities and
demonstrates that the cardiovascular-focused GO annotations, created over the past three years, have led to an evident
improvement of microarray interpretation. The reanalysis of
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