the impact of genetic relationship information on genomic breeding values in german holstein cattle亲缘关系的影响在德国荷斯坦牛基因组育种值的信息.pdfVIP

Habier et al. Genetics Selection Evolution 2010, 42:5 Ge n e t i c s /content/42/1/5 Se l e c t i o n Evolution RESEARCH Open Access The impact of genetic relationship information on genomic breeding values in German Holstein cattle 1* 1 2 3 1 David Habier , Jens Tetens , Franz-Reinhold Seefried , Peter Lichtner , Georg Thaller Abstract Background: The impact of additive-genetic relationships captured by single nucleotide polymorphisms (SNPs) on the accuracy of genomic breeding values (GEBVs) has been demonstrated, but recent studies on data obtained from Holstein populations have ignored this fact. However, this impact and the accuracy of GEBVs due to linkage disequilibrium (LD), which is fairly persistent over generations, must be known to implement future breeding programs. Materials and methods: The data set used to investigate these questions consisted of 3,863 German Holstein bulls genotyped for 54,001 SNPs, their pedigree and daughter yield deviations for milk yield, fat yield, protein yield and somatic cell score. A cross-validation methodology was applied, where the maximum additive-genetic relationship (amax) between bulls in training and validation was controlled. GEBVs were estimated by a Bayesian model averaging approach (BayesB) and an animal model using the genomic relationship matrix (G-BLUP). The accuracy of GEBVs due to LD was estimated by a regression approach using accuracy of GEBVs and