原创力文档the impact of entropy on the spatial organization of synaptonemal complexes within the cell nucleus熵的空间组织的影响synaptonemal复合物在细胞核内.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
the impact of entropy on the spatial organization of synaptonemal complexes within the cell nucleus熵的空间组织的影响synaptonemal复合物在细胞核内
The Impact of Entropy on the Spatial Organization of
Synaptonemal Complexes within the Cell Nucleus
1 2 2 2 ¨ 2¤
Miriam Fritsche *, Laura G. Reinholdt , Mark Lessard , Mary Ann Handel , Jorg Bewersdorf *,
Dieter W. Heermann1,2,3
1 Institute for Theoretical Physics, University of Heidelberg, Heidelberg, Germany, 2 The Jackson Laboratory, Bar Harbor, Maine, United States of America,
3 Interdisciplinary Center for Scientific Computing, Heidelberg, Germany
Abstract
We employ 4Pi-microscopy to study SC organization in mouse spermatocyte nuclei allowing for the three-dimensional
reconstruction of the SC’s backbone arrangement. Additionally, we model the SCs in the cell nucleus by confined, self-
avoiding polymers, whose chain ends are attached to the envelope of the confining cavity and diffuse along it. This work
helps to elucidate the role of entropy in shaping pachytene SC organization. The framework provided by the complex
interplay between SC polymer rigidity, tethering and confinement is able to qualitatively explain features of SC organization,
such as mean squared end-to-end distances, mean squared center-of-mass distances, or SC density distributions. However,
it fails in correctly assessing SC entanglement within the nucleus. In fact, our analysis of the 4Pi-microscopy images reveals a
higher ordering of SCs within the nuclear volume than what is expected by our numerical model. This suggests that while
effects of entropy impact SC organization, the dedicated action of proteins or actin cables is required to fine-tune the spatial
ordering of SCs within the cell nucleus.
Citation: Fritsche M, Reinholdt LG, Lessard M, Handel MA,
您可能关注的文档
- the function and three-dimensional structure of a thromboxane a2cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite功能和三维结构的凝血恶烷a2cysteinyl leukotriene-binding唾液的蛋白质疟原虫的蚊子.pdf
- the functional consequences of mutualistic network architecture互惠网络体系结构的功能结果.pdf
- the function of remote sensing in support of environmental policy遥感的作用在环境政策的支持.pdf
- the function of copulatory plugs in caenorhabditis remanei hints for female benefits交配栓的作用在秀丽隠remanei暗示女性的好处.pdf
- the functional genomic response of developing embryonic submandibular glands to nfκb inhibition发展中胚胎颌下腺体的功能基因组反应nfκb抑制.pdf
- the functional interaction between acyl-coa synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth a novel therapeutic target酰coa合成酶4之间的功能互动,5-lipooxygenase和cyclooxygenase-2控制肿瘤生长一个新颖的治疗目标.pdf
- the functional microarchitecture of the mouse barrel cortex鼠标的功能微体系结构筒皮层.pdf
- the functional response of a generalist predator一个多面手的功能反应捕食者.pdf
- the function and structure of the cerebrospinal fluid outflow system脑脊液流出系统的功能和结构.pdf
- the functional domain of gcs1-based gamete fusion resides in the amino terminus in plant and parasite species的功能域gcs1-based配子融合驻留在植物的氨基酸和寄生虫的物种.pdf
- the impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis a prospective observational study的影响符合6小时和24小时败血症包对医院死亡率严重脓毒症患者的前瞻性研究.pdf
- the impact of focused gene ontology curation of specific mammalian systems集中的影响基因本体特定的哺乳动物系统的管理.pdf
- the impact of genetic relationship information on genomic breeding values in german holstein cattle亲缘关系的影响在德国荷斯坦牛基因组育种值的信息.pdf
- the impact of empiric antimicrobial therapy with a β-lactam and fluoroquinolone on mortality for patients hospitalized with severe pneumonia经验性抗生素疗法的影响β-lactam和氟喹诺酮类患者住院重症肺炎的死亡率.pdf
- the impact of gpx1 on the association of groundwater selenium and depression a project frontier studygpx1影响地下水协会硒和抑郁的一个项目前沿研究.pdf
- the impact of escaped farmed atlantic salmon (salmo salar l.) on catch statistics in scotland逃的影响养殖的大西洋鲑鱼(大西洋鲑l .)统计在苏格兰.pdf
- the impact of field size on the environment and energy crop production efficiency for a sustainable indigenous bioenergy supply chain in the republic of ireland字段长度的影响对环境和能源作物生产可持续的土著生物能源供应链效率的爱尔兰共和国.pdf
- the impact of heat waves on mortality in 9 european cities results from the euroheat project热浪对死亡率的影响在9个欧洲城市euroheat项目的结果.pdf
- the impact of hiv-associated lipodystrophy on healthcare utilization and costs艾滋病的影响脂肪代谢障碍对医疗利用率和成本.pdf
- the impact of hla-drb1 genes on extra-articular disease manifestations in rheumatoid arthritishla-drb1基因的影响在风湿性关节炎疾病关节外表现.pdf
文档评论（0）