原创力文档the impact of statin use on pneumonia risk and outcome a combined population-based case-control and cohort study他汀类药物使用的影响肺炎风险和结果以人群为基础的病例对照和队列研究.pdfVIP
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the impact of statin use on pneumonia risk and outcome a combined population-based case-control and cohort study他汀类药物使用的影响肺炎风险和结果以人群为基础的病例对照和队列研究
Nielsen et al. Critical Care 2012, 16:R122
/content/16/4/R122
RESEARCH Open Access
The impact of statin use on pneumonia risk and
outcome: a combined population-based case-
control and cohort study
Anders Gunnar Nielsen, Rikke Beck Nielsen, Anders Hammerich Riis, Søren Paaske Johnsen, Henrik Toft Sørensen
*
and Reimar Wernich Thomsen
Abstract
Introduction: The impact of statin use on pneumonia risk and outcome remains unclear. We therefore examined
this risk in a population-based case-control study and did a 5-year update of our previous 30-day mortality
analyses.
Methods: We identified 70,953 adults with a first-time hospitalization for pneumonia between 1997 and 2009 in
Northern Denmark. Ten age- and sex-matched population controls were selected for each pneumonia patient. To
control for potential confounders, we retrieved individual-level data on other medications, comorbidities, recent
surgery, socioeconomic indicators, influenza vaccination, and other markers of frailty or health awareness from
medical databases. We followed all pneumonia patients for 30 days after hospital admission.
Results: A total of 7,223 pneumonia cases (10.2%) and 64 523 controls (9.1%) were statin users before admission,
corresponding to an age- and sex-matched odds ratio (OR) of 1.17 (95% confidence interval [CI]: 1.14-1.21). After
controlling for higher comorbidity and a wide range of other potential confounders, the adjusted OR for
pneumonia associated with current statin use dropped to 0.80 (95% CI: 0.77-0.83). Previous statin use was not
associated with decreased pneumonia risk (adjusted OR = 0.97, 95% CI: 0.91-1.02). Decreased risk remained
significant after further adjustment for frailty and health awareness markers.
The prevalence of statin use among Danish pneumonia patients inc
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