unexpected diversity of cellular immune responses against nef and vif in hiv-1-infected patients who spontaneously control viral replication意想不到的细胞免疫反应和nef vif多样性hiv-1-infected患者自发控制病毒的复制.pdfVIP

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unexpected diversity of cellular immune responses against nef and vif in hiv-1-infected patients who spontaneously control viral replication意想不到的细胞免疫反应和nef vif多样性hiv-1-infected患者自发控制病毒的复制.pdf

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unexpected diversity of cellular immune responses against nef and vif in hiv-1-infected patients who spontaneously control viral replication意想不到的细胞免疫反应和nef vif多样性hiv-1-infected患者自发控制病毒的复制

Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication 1 2 3 2 2 Leandro F. Tarosso , Mariana M. Sauer , Sabri Sanabani , Maria Teresa Giret , Helena I. Tomiyama , 4 5 2 3 4 John Sidney , Shari M. Piaskowski , Ricardo S. Diaz , Ester C. Sabino , Alessandro Sette , Jorge 1 5 1,2 Kalil-Filho , David I. Watkins , Esper G. Kallas * 1 Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil, 2 Division of Infectious Diseases, Federal University of Sao Paulo, Sao Paulo, Brazil, 3 Sao Paulo Blood Bank, Sao Paulo, Brazil, 4 La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America, 5 Department of Pathology, Medical School, University of Wisconsin-Madison, Madison, Wisconsin, United States of America Abstract Background: HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus. Methodology and Principal Findings: