原创力文档understanding the selectivity mechanism of the human asialoglycoprotein receptor (asgp-r) toward gal- and man- type ligands for predicting interactions with exogenous sugars理解人类asialoglycoprotein受体的选择性机制(asgp-r)向加-和人型配体预测与外源性糖的交互.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
understanding the selectivity mechanism of the human asialoglycoprotein receptor (asgp-r) toward gal- and man- type ligands for predicting interactions with exogenous sugars理解人类asialoglycoprotein受体的选择性机制(asgp-r)向加-和人型配体预测与外源性糖的交互
Int. J. Mol. Sci. 2007, 8, 13-28
International Journal of
Molecular Sciences
ISSN 1422-0067
© 2007 by MDPI
/ijms/
Understanding the Selectivity Mechanism of the Human
Asialoglycoprotein Receptor (ASGP-R) toward Gal- and Man-
type Ligands for Predicting Interactions with Exogenous Sugars
Ilaria Massarelli 1, Laura Murgia 1, Anna Maria Bianucci 2, Federica Chiellini 1 and Emo
Chiellini 1,*
1 Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Risorgimento 35, 56126 Pisa,
Italy. E-mail: ilaria@dcci.unipi.it; lauram@dcci.unipi.it; federica@dcci.unipi.it; emochie@dcci.unipi.it
2 Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy. E-mail:
bianucci@farm.unipi.it
* Author to whom correspondence should be addressed. E-Mail: emochie@dcci.unipi.it
Received: 2 August 2006, in revised form: 10 November 2006 / Accepted: 14 December 2006 /
Published: 29 January 2007
Abstract: A practical approach for addressing the computer simulation of protein-
carbohydrate interactions is described here. An articulated computational protocol was set
up and validated by checking its ability to predict experimental data, available in the
literature, and concerning the selectivity shown by the Carbohydrate Recognition Domain
(CRD) of the human asialoglycoprotein receptor (ASGP-R) toward Gal-type ligands. Some
您可能关注的文档
- the hiv-1 vpu viroporin inhibitor bit225 does not affect vpu-mediated tetherin antagonism的hiv - 1 vpu viroporin抑制剂bit225并不影响vpu-mediated tetherin对抗.pdf
- the homeobox transcription factor barx2 regulates plasticity of young primary myofibers同源框转录因子barx2调节年轻主要肌纤维可塑性.pdf
- the homer family proteins荷马家族蛋白质.pdf
- the hope and the promise of the un resolution on non-communicable diseases希望和承诺的联合国关于非传染性疾病的决议.pdf
- the hla class ii allele drb11501 is over-represented in patients with idiopathic pulmonary fibrosishla二类等位基因drb11501是特发性肺纤维化患者占大多数.pdf
- the homozygote vcpr155hr155h mouse model exhibits accelerated human vcp-associated disease pathology纯合体vcpr155hr155h鼠标模型展览加速人类vcp-associated疾病病理学.pdf
- the honey bee epigenomes differential methylation of brain dna in queens and workers蜜蜂表观基因组差异dna甲基化的大脑在皇后区和工人.pdf
- the hopes of west african refugees during resettlement in northern sweden a 6-year prospective qualitative study of pathways and agency thoughts西非的希望难民安置在瑞典北部的六年前瞻性定性研究途径和机构的想法.pdf
- the hospital anxiety and depression rating scale a cross-sectional study of psychometrics and case finding abilities in general practice医院的焦虑和抑郁心理评定量表横断面研究和发现病例的能力练习.pdf
- the homeodomain protein defective proventriculus is essential for male accessory gland development to enhance fecundity in drosophilahomeodomain蛋白缺陷前胃男性附属腺的发展至关重要,加强果蝇的繁殖能力.pdf
- unexpected high genetic diversity at the extreme northern geographic limit of taurulus bubalis (euphrasen, 1786)意想不到的高遗传多样性的地理限制taurulus狷羚(euphrasen,1786).pdf
- unexpected inheritance multiple integrations of ancient bornavirus and ebolavirusmarburgvirus sequences in vertebrate genomes意想不到的继承古代bornavirus和ebolavirusmarburgvirus的多个集成在脊椎动物的基因组序列.pdf
- unexpected long-term protection of adult offspring born to high-fat fed dams against obesity induced by a sucrose-rich diet意想不到的长期保护的成年后代出生高脂肪美联储水坝对sucrose-rich饮食导致的肥胖.pdf
- unexpected instability of family of repeats (fr), the critical cis-acting sequence required for ebv latent infection, in ebv-bac systems意想不到的家庭不稳定重复(fr),所需的临界cis-acting序列ebv潜伏性感染,ebv-bac系统.pdf
- unfakeable facial configurations affect strategic choices in trust games with or without information about past behavior不能造假面部配置影响信任游戏的战略选择有或没有过去的行为的信息.pdf
- unfolded protein responses with or without unfolded proteins展开的蛋白质反应有或没有展开的蛋白质.pdf
- understanding the evolution of mammalian brain structures; the need for a (new) cerebrotype approach了解哺乳动物大脑的进化结构;.pdf
- unfolding visual lexical decision in time展开视觉词汇的决定.pdf
- unidrug-target a computational tool to identify unique drug targets in pathogenic bacteriaunidrug-target计算工具在病原菌识别独特的药物靶点.pdf
- unfolding of the amyloid β-peptide central helix mechanistic insights from molecular dynamics simulations展开的淀粉样蛋白β-peptide中央螺旋机械的见解从分子动力学模拟.pdf
文档评论（0）