原创力文档unidrug-target a computational tool to identify unique drug targets in pathogenic bacteriaunidrug-target计算工具在病原菌识别独特的药物靶点.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
unidrug-target a computational tool to identify unique drug targets in pathogenic bacteriaunidrug-target计算工具在病原菌识别独特的药物靶点
UniDrug-Target: A Computational Tool to Identify
Unique Drug Targets in Pathogenic Bacteria
Sree Krishna Chanumolu, Chittaranjan Rout, Rajinder S. Chauhan*
Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India
Abstract
Background: Targeting conserved proteins of bacteria through antibacterial medications has resulted in both the
development of resistant strains and changes to human health by destroying beneficial microbes which eventually become
breeding grounds for the evolution of resistances. Despite the availability of more than 800 genomes sequences, 430
pathways, 4743 enzymes, 9257 metabolic reactions and protein (three-dimensional) 3D structures in bacteria, no pathogen-
specific computational drug target identification tool has been developed.
Methods: A web server, UniDrug-Target, which combines bacterial biological information and computational methods to
stringently identify pathogen-specific proteins as drug targets, has been designed. Besides predicting pathogen-specific
proteins essentiality, chokepoint property, etc., three new algorithms were developed and implemented by using protein
sequences, domains, structures, and metabolic reactions for construction of partial metabolic networks (PMNs),
determination of conservation in critical residues, and variation analysis of residues forming similar cavities in proteins
sequences. First, PMNs are constructed to determine the extent of disturbances in metabolite production by targeting a
protein as drug target. Conservation of pathogen-specific protein’s critical residues involved in cavity formation and
biological function determined at domain-level with low-matching sequences. Last, variation analysis of
您可能关注的文档
- the hr1 and fusion peptide regions of the subgroup b avian sarcoma and leukosis virus envelope glycoprotein influence low ph-dependent membrane fusion子群的hr1上和融合肽区域b禽流感肉瘤和白血病病毒包膜糖蛋白的影响低ph-dependent膜融合.pdf
- the hrpz gene of pseudomonas syringae pv. phaseolicola enhances resistance to rhizomania disease in transgenic nicotiana benthamiana and sugar beet丁香假单胞菌的hrpz基因。.pdf
- the hoxb4 homeoprotein promotes the ex vivo enrichment of functional human embryonic stem cell-derived nk cells的hoxb4 homeoprotein促进功能人类胚胎干细胞的体外浓缩nk细胞.pdf
- the hsp90 co-chaperone sgt1 governs candida albicans morphogenesis and drug resistance的一半co-chaperone sgt1控制白色念珠菌形态发生和耐药.pdf
- the hschsp70 co-chaperone network controls antigen aggregation and presentation during maturation of professional antigen presenting cells期间的hschsp70 co-chaperone网络控制抗原聚合和呈现成熟专业的抗原呈递细胞.pdf
- the htra-like serine protease pepd interacts with and modulates the mycobacterium tuberculosis 35-kda antigen outer envelope protein的htra-like丝氨酸蛋白酶pepd与结核分枝杆菌,调节35-kda外层包膜蛋白抗原.pdf
- the htlv-1 virological synapsehtlv 1病毒学的突触.pdf
- the hsv-1 exonuclease, ul12, stimulates recombination by a single strand annealing mechanism1型单纯疱疹病毒核酸外切酶、ul12刺激由单一链重组退火机制.pdf
- the human airway epithelial basal cell transcriptome人类的气道上皮基底细胞转录组.pdf
- the human adenovirus type 5 e1b 55 kda protein obstructs inhibition of viral replication by type i interferon in normal human cells人类腺病毒5型e1b 55 kda蛋白质阻碍抑制病毒复制的i型干扰素在正常的人类细胞.pdf
- unfolding of the amyloid β-peptide central helix mechanistic insights from molecular dynamics simulations展开的淀粉样蛋白β-peptide中央螺旋机械的见解从分子动力学模拟.pdf
- uniaxial tension test of slender reinforced early age concrete members单轴拉伸试验的细长钢筋混凝土早期成员.pdf
- uniform silica coated fluorescent nanoparticles synthetic method, improved light stability and application to visualize lymph network tracer均匀涂二氧化硅荧光纳米粒子的合成方法,改进的光稳定性和应用可视化网络淋巴示踪剂.pdf
- unifying candidate gene and gwas approaches in asthma统一的候选基因在哮喘和gwas的方法.pdf
- unexpected high losses of anopheles gambiae larvae due to rainfall意想不到的高损失的冈比亚疟蚊幼虫由于降雨.pdf
- unexpected neuronal protection of su5416 against 1-methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase意想不到的神经保护su5416反对1-methyl-4-phenylpyridinium离子感应通过抑制神经元一氧化氮合酶的毒性.pdf
- unintended consequences of conservation actions managing disease in complex ecosystems意想不到的后果的保护行动管理疾病的复杂生态系统.pdf
- unifying gene expression measures from multiple platforms using factor analysis统一的基因表达措施使用因子分析从多个平台.pdf
- unique c2v3 sequence in hiv-1 envelope obtained from broadly neutralizing plasma of a slow progressing patient conferred enhanced virus neutralization独特c2v3序列在hiv - 1信封里获得广泛中和等离子的缓慢进展患者授予增强病毒中和.pdf
- unfaithful maintenance of methylation imprints due to loss of maternal nuclear dnmt1 during somatic cell nuclear transfer不忠的维护甲基化痕迹由于损失的孕产妇核dnmt1在体细胞核移植.pdf
文档评论（0）