the hoxb4 homeoprotein promotes the ex vivo enrichment of functional human embryonic stem cell-derived nk cells的hoxb4 homeoprotein促进功能人类胚胎干细胞的体外浓缩nk细胞.pdfVIP
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the hoxb4 homeoprotein promotes the ex vivo enrichment of functional human embryonic stem cell-derived nk cells的hoxb4 homeoprotein促进功能人类胚胎干细胞的体外浓缩nk细胞
The HOXB4 Homeoprotein Promotes the Ex Vivo
Enrichment of Functional Human Embryonic Stem Cell-
Derived NK Cells
1 2 ´ 3,4,5 6 ´ 1
Aniya Larbi , Jean-Marc Gombert , Celine Auvray , Bruno l’Homme , Aurelie Magniez ,
´ 1 1 6 1 1,2
Olivier Feraud , Laure Coulombel , Alain Chapel , Maria Teresa Mitjavila-Garcia , Ali G. Turhan ,
1,7 . 1,7,8.
Rima Haddad * , Annelise Bennaceur-Griscelli
´
1 Inserm UMR 935, « ESTeam Paris Sud », Stem Cell Core Facility Institut Andre Lwoff, University Paris Sud 11, Paul Brousse Hospital, Villejuif, France, 2 Inserm UMR 935,
University of Poitiers, CHU Poitiers, Poitiers, France, 3 Inserm U1016, Institut Cochin, Paris, France, 4 Cnrs UMR 8104, Paris, France, 5 University Paris Descartes, Sorbonne
´
Paris Cite, France, 6 IRSN, PRP-HOM, SRBE, Laboratory of Radiopathology and experimental therapies, Fontenay aux Roses, France, 7 University Paris Sud 11, Faculty of
ˆ
Medicine, Kremlin-Bicetre, France, 8 AP-HP, Laboratory of Hematology, University Hospitals Paris Sud, Paul Brousse Hospital, Villejuif, France
Abstract
Human embryonic stem cells (hESCs) can be induced to differentiate into blood cells using either co-culture with stromal
cells or following human embryoid bodies (hEBs) formation. It is now well established that the HOXB4 homeoprotein
promotes the expansion of human adult hematopoietic stem cells
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