原创力文档the hr1 and fusion peptide regions of the subgroup b avian sarcoma and leukosis virus envelope glycoprotein influence low ph-dependent membrane fusion子群的hr1上和融合肽区域b禽流感肉瘤和白血病病毒包膜糖蛋白的影响低ph-dependent膜融合.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
the hr1 and fusion peptide regions of the subgroup b avian sarcoma and leukosis virus envelope glycoprotein influence low ph-dependent membrane fusion子群的hr1上和融合肽区域b禽流感肉瘤和白血病病毒包膜糖蛋白的影响低ph-dependent膜融合
The hr1 and Fusion Peptide Regions of the Subgroup B
Avian Sarcoma and Leukosis Virus Envelope
Glycoprotein Influence Low pH-Dependent Membrane
Fusion
1 2 3
Angeline Rose Babel , James Bruce , John A. T. Young *
1 McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America,
2 Institute for Molecular Virology, Bock Laboratories, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 3 Infectious
Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
The avian sarcoma and leukosis virus (ASLV) envelope glycoprotein (Env) is activated to trigger fusion by a two-step
mechanism involving receptor-priming and low pH fusion activation. In order to identify regions of ASLV Env that can regulate
this process, a genetic selection method was used to identify subgroup B (ASLV-B) virus-infected cells resistant to low pH-
triggered fusion when incubated with cells expressing the cognate TVB receptor. The subgroup B viral Env (envB) genes were
then isolated from these cells and characterized by DNA sequencing. This led to identification of two frequent EnvB alterations
which allowed TVB receptor-binding but altered the pH-threshold of membrane fusion activation: a 13 amino acid deletion in
the host range 1 (hr1) region of the surface (SU) EnvB subunit, and the A32V amino acid change within the fusion peptide of
the transmembrane (TM) EnvB subunit. These data indicate that these two regions of EnvB can influence the pH threshold of
fusion activation.
Citation: Babel AR, Bruce J, Young JAT (2007) The hr1 and Fusion Peptide Regions of the Subgroup B Avian Sarcoma and Leukosis Virus Envelope
Glycoprotein Influence Low pH-Dependent Membrane Fusion. PLoS ONE 2(1): e171. doi:10.1371/journ
您可能关注的文档
- the eyes have it regulatory and structural changes both underlie cichlid visual pigment diversity眼睛有监管和结构性变化都是丽鱼科鱼的视觉色素的多样性的基础.pdf
- the fat mass and obesity associated gene, fto, is also associated with osteoporosis phenotypesfto,脂肪量和肥胖相关基因也与骨质疏松相关的表型.pdf
- the f-box protein family盒蛋白家族.pdf
- the feasibility and impact of delivering a mind-body intervention in a virtual world交付一个身心干预的可行性和影响在一个虚拟的世界.pdf
- the fat mass and obesity associated gene fto functions in the brain to regulate postnatal growth in micefto基因功能相关的脂肪量和肥胖老鼠大脑中调节产后增长.pdf
- the feasibility and validity of ambulatory self-report of psychotic symptoms using a smartphone software application动态自我报告的可行性和有效性的精神病症状使用智能手机的软件应用程序.pdf
- the fbpasapm double knock out strain of mycobacterium tuberculosis is highly attenuated and immunogenic in macrophagesfbpasapm双敲除株结核分枝杆菌高度减毒和巨噬细胞的免疫原性.pdf
- the feasibility of enzyme targeted activation for amino aciddipeptide monoester prodrugs of floxuridine; cathepsin d as a potential targeted enzyme对氨基酶的可行性目标激活aciddipeptide单酯高活性氟尿苷;.pdf
- the feasibility of a single-blinded fast-track pragmatic randomised controlled trial of a complex intervention for breathlessness in advanced disease单盲快速实用的随机对照试验的可行性先进复杂干预呼吸困难的疾病.pdf
- the feasibility of preventing mother-to-child transmission of hiv using peer counselors in zimbabwe防止艾滋病毒母婴传播的使用同行的可行性顾问在津巴布韦.pdf
- the hrpz gene of pseudomonas syringae pv. phaseolicola enhances resistance to rhizomania disease in transgenic nicotiana benthamiana and sugar beet丁香假单胞菌的hrpz基因。.pdf
- the hoxb4 homeoprotein promotes the ex vivo enrichment of functional human embryonic stem cell-derived nk cells的hoxb4 homeoprotein促进功能人类胚胎干细胞的体外浓缩nk细胞.pdf
- the hsp90 co-chaperone sgt1 governs candida albicans morphogenesis and drug resistance的一半co-chaperone sgt1控制白色念珠菌形态发生和耐药.pdf
- the hschsp70 co-chaperone network controls antigen aggregation and presentation during maturation of professional antigen presenting cells期间的hschsp70 co-chaperone网络控制抗原聚合和呈现成熟专业的抗原呈递细胞.pdf
- the htra-like serine protease pepd interacts with and modulates the mycobacterium tuberculosis 35-kda antigen outer envelope protein的htra-like丝氨酸蛋白酶pepd与结核分枝杆菌,调节35-kda外层包膜蛋白抗原.pdf
- the htlv-1 virological synapsehtlv 1病毒学的突触.pdf
- the hsv-1 exonuclease, ul12, stimulates recombination by a single strand annealing mechanism1型单纯疱疹病毒核酸外切酶、ul12刺激由单一链重组退火机制.pdf
- the human airway epithelial basal cell transcriptome人类的气道上皮基底细胞转录组.pdf
- the human adenovirus type 5 e1b 55 kda protein obstructs inhibition of viral replication by type i interferon in normal human cells人类腺病毒5型e1b 55 kda蛋白质阻碍抑制病毒复制的i型干扰素在正常的人类细胞.pdf
- the human allergens of mesquite (prosopis juliflora)豆科灌木的人类过敏原(prosopis juliflora).pdf
文档评论（0）