upregulation of xct by kshv-encoded micrornas facilitates kshv dissemination and persistence in an environment of oxidative stressupregulation kshv-encoded xct的microrna促进kshv传播和持久性的环境中氧化应激.pdfVIP

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upregulation of xct by kshv-encoded micrornas facilitates kshv dissemination and persistence in an environment of oxidative stressupregulation kshv-encoded xct的microrna促进kshv传播和持久性的环境中氧化应激.pdf

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upregulation of xct by kshv-encoded micrornas facilitates kshv dissemination and persistence in an environment of oxidative stressupregulation kshv-encoded xct的microrna促进kshv传播和持久性的环境中氧化应激

Upregulation of xCT by KSHV-Encoded microRNAs Facilitates KSHV Dissemination and Persistence in an Environment of Oxidative Stress 1,2 1 1 1 3 3 Zhiqiang Qin , Eduardo Freitas , Roger Sullivan , Sarumathi Mohan , Rocky Bacelieri , Drake Branch , 4 1 1,5 6 6 7 Margaret Romano , Patricia Kearney , Jim Oates , Karlie Plaisance , Rolf Renne , Johnan Kaleeba *, Chris Parsons1,2* 1 Department of Medicine, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America, 2 Department of Craniofacial Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America, 3 Department of Dermatology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America, 4 Department of Pathology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America, 5 Medical Service, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, United States of America, 6 Department of Molecular Genetics and Microbiology, Shands Cancer Center, University of Florida, Gainesville, Florida, United States of America, 7 Departments of Microbiology and Immunology and Molecular/Cell Biology, Uniformed Services University of the Health Sciences, F. Edward Herbert School of Medicine, Bethesda, Maryland, United States of America Abstract Upregulation of xCT, the inducible subunit of a membrane-bound amino acid transporter, replenishes intracellular glutathione stores to maintain cell via