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vaccine potential of nipah virus-like particles尼帕病毒样颗粒疫苗的潜力
Vaccine Potential of Nipah Virus-Like Particles
1 2 3 4 2
Pramila Walpita *, Jennifer Barr , Michael Sherman , Christopher F. Basler , Linfa Wang
1 Departments of Microbiology and Immunology, Center for Biodefense and Emerging Infectious Disease, University of Texas Medical Branch, Galveston, Texas, United
States of America, 2 Australian Commonwealth Scientific and Industrial Research Organization, Australian Animal Health Laboratory, Geelong, Victoria, Australia,
3 Department of Biochemistry and Structural Biology, University of Texas Medical Branch, Galveston, Texas, United States of America, 4 Department of Microbiology,
Mount Sinai School of Medicine, New York, New York, United States of America
Abstract
Nipah virus (NiV) was first recognized in 1998 in a zoonotic disease outbreak associated with highly lethal febrile
encephalitis in humans and a predominantly respiratory disease in pigs. Periodic deadly outbreaks, documentation of
person-to-person transmission, and the potential of this virus as an agent of agroterror reinforce the need for effective
means of therapy and prevention. In this report, we describe the vaccine potential of NiV virus-like particles (NiV VLPs)
composed of three NiV proteins G, F and M. Co-expression of these proteins under optimized conditions resulted in
quantifiable amounts of VLPs with many virus-like/vaccine desirable properties including some not previously described for
VLPs of any paramyxovirus: The particles were fusogenic, inducing syncytia formation; PCR array analysis showed NiV VLP-
induced activation of innate immune defense pathways; the surface structure of NiV VLPs image
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