原创力文档weight gain is associated with medial contact site of subthalamic stimulation in parkinsons disease体重增加与内侧丘脑下的刺激在帕金森病的联系.pdfVIP
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weight gain is associated with medial contact site of subthalamic stimulation in parkinsons disease体重增加与内侧丘脑下的刺激在帕金森病的联系
Weight Gain Is Associated with Medial Contact Site of
Subthalamic Stimulation in Parkinson’s Disease
˚ ˇ ˇ 1. 1 . ´ ´ 1 ˇ ˇ ´ 2 3 ˇ ˚ ˇ ˇ 1
Filip Ruzicka , Robert Jech * , Lucie Novakova , Dusan Urgosık , Josef Vymazal , Evzen Ruzicka
1 Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine and General University Hospital, Charles University, Prague, Czech Republic,
2 Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic, 3 Department of Radiology, Na Homolce Hospital, Prague, Czech
Republic
Abstract
The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the
subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson’s disease
within a period of 18 months after implantation. T1-weighted (1.5T) magnetic resonance images were used to determine
electrode position in the subthalamic nucleus and the Unified Parkinson’s disease rating scale (UPDRS-III) was used for
motor assessment. The distance of the contacts from the wall of the third ventricle in the mediolateral direction inversely
correlated with weight gain (r = 20.55, p,0.01) and with neurostimulation-related motor condition expressed as the
contralateral hemi-body UPDRS-III (r = 20.42, p,0.01). Patients with at least one contact within 9.3 mm of the wall
experienced significantly greater weight gain (9.4 6(SD)4.4 kg, N = 11) than those with both contacts
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