weighted change-point method for detecting differential gene expression in breast cancer microarray data加权变点检测微分方法在乳腺癌微阵列基因表达数据.pdfVIP

Weighted Change-Point Method for Detecting Differential Gene Expression in Breast Cancer Microarray Data 1 2 3,4 1,5 1 Yao Wang , Guang Sun , Zhaohua Ji , Chong Xing , Yanchun Liang * 1 Key Laboratory for Symbol Computation and Knowledge Engineering of National Education Ministry, College of Computer Science and Technology, Jilin University, Changchun, China, 2 Department of Breast and Thyroid Surgery, China-Japan Union Hospital, Changchun, China, 3 Department of Communication Engineering, Jilin University, Changchun, China, 4 College of Computer Science and Technology, Inner Mongolia Normal University, Huhhot, China, 5 Guanghua College of Changchun University, Changchun, China Abstract In previous work, we proposed a method for detecting differential gene expression based on change-point of expression profile. This non-parametric change-point method gave promising result in both simulation study and public dataset experiment. However, the performance is still limited by the less sensitiveness to the right bound and the statistical significance of the statistics has not been fully explored. To overcome the insensitiveness to the right bound we modified the original method by adding a weight function to the Dn statistic. Simulation study showed that the weighted change- point statistics method is significantly better than the original NPCPS in terms of ROC, false positive rate, as well as change- point estimate. The mean absolute error of the estimated change-point by weighted change-point method was 0.03, reduced by more than 50% comparing with the original 0.06, and the mean FPR was reduced by more than 55%. Experiment on microarray Dataset I resulted in 3974 differentially ex