control of cyclin c levels during development of dictyostelium盘基网柄菌控制细胞周期蛋白c水平在发展.pdfVIP

Control of Cyclin C Levels during Development of Dictyostelium David M. Greene, Duen-Wei Hsu, Catherine J. Pears* Department of Biochemistry, University of Oxford, Oxford, United Kingdom Abstract Background: Cdk8 and its partner cyclin C form part of the mediator complex which links the basal transcription machinery to regulatory proteins. The pair are required for correct regulation of a subset of genes and have been implicated in control of development in a number of organisms including the social amoeba Dictyostelium discoideum