defining the role of essential genes in human disease定义基本基因在人类疾病的作用.pdfVIP

Defining the Role of Essential Genes in Human Disease Jonathan E. Dickerson.¤a, Ana Zhu.¤b, David L. Robertson, Kathryn E. Hentges* Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom Abstract A greater understanding of the causes of human disease can come from identifying characteristics that are specific to disease genes. However, a full understanding of the contribution of essential genes to human disease is lacking, due to the premise that these genes tend to cause developmental abnormalities rather than adult disease.