differential association between herg and kcne1 or kcne2微分herg和kcne1或kcne2之间的联系.pdfVIP

Differential Association between HERG and KCNE1 or KCNE2 Sung Yon Um1,2, Thomas V. McDonald1,2* 1 Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America The small proteins encoded by KCNE1 and KCNE2 have both been proposed as accessory subunits for the HERG channel. Here we report our investigation into the cell biology of the KCNE-HERG interaction. In a co-expression system, KCNE1 was more readily co-precipitated with