原创力文档directed evolution of the transcriptional regulator dntr isolation of mutants with improved dnt-response定向进化突变体的转录监管机构dntr隔离,dnt-response有所改善.pdfVIP
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directed evolution of the transcriptional regulator dntr isolation of mutants with improved dnt-response定向进化突变体的转录监管机构dntr隔离,dnt-response有所改善
Directed Evolution of the Transcriptional Regulator DntR:
Isolation of Mutants with Improved DNT-Response
¨
Rosa Lonneborg*, Edina Varga, Peter Brzezinski*
Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden
Abstract
The transcriptional regulator DntR, which previously has been isolated from bacterial strains capable of degrading 2,4-
dinitrotoluene (DNT), was engineered in order to improve the ability to detect DNT. A directed evolution strategy was
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