domain altering snps in the human proteome and their impact on signaling pathways域在人类蛋白质组改变单核苷酸多态性及其对信号通路的影响.pdfVIP

Domain Altering SNPs in the Human Proteome and Their Impact on Signaling Pathways Yichuan Liu, Aydin Tozeren* Center for Integrated Bioinformatics, Drexel University, Philadelphia, Pennsylvania, United States of America Abstract Single nucleotide polymorphisms (SNPs) constitute an important mode of genetic variations observed in the human genome. A small fraction of SNPs, about four thousand out of the ten million, has been associated with genetic disorders and complex diseases. The present study focuses on SNPs that fall on protein domains