elevated 17β-estradiol protects females from influenza a virus pathogenesis by suppressing inflammatory responses高17β-estradiol保护女性免受甲型流感病毒发病机制通过抑制炎症反应.pdfVIP

Elevated 17b-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses Dionne P. Robinson, Maria E. Lorenzo, William Jian, Sabra L. Klein* W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America Abstract Studies of the 1918 H1N1 influenza pandemic, the H5N1 avian influenza outbreak, and the 2009 H1N1 pandemic illustrate that sex and pregnancy contribute to severe outcome from infection, suggesting a rol