05大环内酯类（05 macrolides）.doc

05大环内酯类（05 macrolides） Doctor of antibiotics Pharmacopoeia - - macrolides Erythromycin Erythromycin (Ilotycin, Erycin) [function and application] This product is a macrolide antibiotic, antibacterial spectrum and penicillin is similar to gram positive bacteria such as Staphylococcus aureus and hemolytic streptococcus, pneumococcus, Diphtheria Bacillus, Bacillus anthracis, Bacillus fusiformis, has strong antibacterial effect. It has some effects on Gram negative bacteria such as Neisseria meningitidis, Neisseria gonorrhoeae, Bordetella pertussis, Bacillus influenzae, Brucella, some dysentery bacillus and E. coli. A strain that is resistant to penicillin and is sensitive to this product. The mechanism is mainly 50S subunit ribosome combined inhibitory peptide acyltransferase, influence of the shift process ribosomes, hinder peptide growth, inhibiting bacterial protein synthesis, antibacterial agent system. Clinically it is mainly used for penicillin resistant Staphylococcus aureus infection and Staphylococcus aureus infection caused by penicillin. Also for hemolytic streptococcus and pneumococcus caused by respiratory, Legionella pneumonia, mycoplasma pneumonia, skin and soft tissue infections, in addition to diphtheria patients, with this product and Diphtheria Antitoxin is associated with significant effect. [dosage and usage] Erythromycin Tablets (enteric coated tablets) oral administration, adult 1g to 2g/ days; children daily 30mg to 50mg/kg, divided into 3~4 times. Intravenous infusion or intravenous drip can be made with erythromycin Lactobionate (Erythromycin), which is 1g to 2g/ per day, and 20mg to 30mg/kg per day, 2~3 times. [side effects] 1 gastrointestinal reactions can be nausea, vomiting, abdominal pain and diarrhea, the response is related to the size of the dose. 2 allergic reactions can be urticaria and drug fever. 3 can cause liver damage, such as elevated serum alanine aminotransferase, jaundice and so on. 4 intravenous injection or intravenous d