药理学中重要名词解释（Explanation of important nouns in pharmacology）.docVIP

药理学中重要名词解释（Explanation of important nouns in pharmacology） Drug effect dynamics, also known as pharmacodynamics, studies the effects and mechanisms of drugs on the organism. Pharmacokinetics, also called pharmacokinetics, studies the changes and laws of drugs under the influence of the organism. Absorption: the process by which a drug enters the bloodstream through a membrane barrier composed of cells passing from the site of administration. PKa value: the negative value of the dissociation constant; the pH value of a weakly basic or weakly acidic drug ionized at 50% in solution. Ion barrier: non ionic drugs can freely penetrate the cell membrane, while ionic drugs are restricted to one side of the cell membrane and are difficult to cross the cell membrane. This phenomenon is called ion barrier. Elimination of the first pass: after oral absorption, the drug enters the liver through the portal vein to transform, so as to reduce the amount of systemic circulation. Distribution: the process by which drugs are absorbed and transported to tissues throughout the circulation. Aging curve: a curve showing the effect of a drug over time. Plasma half-life: blood concentration decreased by half of the time (t1/2). Bioavailability: - refers to the relative volume and velocity absorbed into the body circulation after removal of the livers first pass. F = A/D, D represents the dosage, and A indicates the dose to enter the systemic circulation. Absolute oral bioavailability: the ratio of extravascular administration of AUC to AUC after intravenous injection. The relative bioavailability of drug dosage forms, the absorption rate of F= reagent, AUC/ standard AUC can be used as medicine, drug quality index appraisal. Zero order elimination kinetics: when the drug in the body too much, the body with its maximum ability to eliminate drugs, elimination rate has nothing to do with the C0, it was at a constant speed (also known as quantitative easing); plasma half-life is not fixed, when