抗血栓药物的研究进展-药学进展.pdfVIP

PROGRESS IN PHARMACEUTICAL SCIENCES 2014,38 3 :174-184 174 ( ) 抗血栓药物的研究进展 邢峻豪，杨凌云，李清，周金培，张惠斌 * （中国药科大学新药研究中心，江苏南京 210009） [ 摘要 ] 血栓栓塞性疾病是引起人类疾病死亡的主要原因之一，随着人们对其发病机制研究与认识的不断深入以及药物设计和筛选技术的日 臻成熟，针对各种靶点的新型抗血栓药物不断涌现，如二磷酸腺苷受体阻滞剂、Ⅹ a 因子抑制剂、凝血酶抑制剂等，我国药学研究者也在 这些靶向抗血栓药物研究领域取得一定进展。综述我国学者近些年在国内外学术期刊上发表的相关研究论文中所涉及的各类新型抗血小板 药物、抗凝血药物和血栓溶解剂的结构、活性和构效关系。 [ 关键词 ] 抗血小板药物；抗凝血药物；血栓溶解剂；结构；活性；构效关系 [ 中图分类号 ]R973.2 [ 文献标志码 ] A [ 文章编号 ] 1001-5094(2014)03-0174-11 Advances in Antithrombotic Drugs XING Junhao, YANG Lingyun, LI Qing, ZHOU Jinpei, ZHANG Huibin (Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China) [Abstract] Thromboembolic disease is one of leading causes of death caused by diseases in humans. As the research and understanding of the pathogenesis is getting deeper and the drug design and screening technology is becoming mature gradually, some new antithrombotic drugs against a variety of targets are constantly emerging, such as adenosine diphosphate (ADP) receptor blockers, factor Xa (FXa) inhibitors and thrombin inhibitors. Pharmaceutical researchers in our country have also made some progress in the research on antithrombotic drugs against these targets. The structures, activities and structure-activity relationships of different types of novel anti-platelet drugs, anticoagulants and thrombolytic agents, which have been reported by Chinese scholars in the related research papers in academic journals both at home and abroad in recent years, were reviewed. [Key words] anti-platelet drug; anticoagulant; thrombolytic agent; structure; activity; structure-activity relationship 血栓栓塞性疾病是目前引起人类疾病死亡的主要原因