麻痹性斜视患者超氧化物歧化酶及丙二醛变化及斜视康泰方对其.docVIP

麻痹性斜视患者超氧化物歧化酶及丙二醛变化及斜视康泰方对其 　 作者：赵建新，田元祥，曹刚，宋桂莲 【摘要】 　　目的观察麻痹性斜视患者血清SOD，MDA的变化以及斜视康泰方对其的影响。方法80例患者被随机分为斜视康泰方治疗组（40例）和对照组（40例）。对照组给予西医常规，治疗组加服斜视康泰方，1剂/d，两组均给药4周统计疗效。并于治疗前后取血测定患者血清SOD，MDA含量。结果麻痹性斜视患者治疗前血清SOD水平在正常范围的低值，MDA水平高于正常值。治疗后，治疗组血清SOD水平提高，MDA水平下降，并在总有效率、主症疗效改善方面优于对照组（均P＜0.05）。结论 斜视康泰方对麻痹性斜视有较好的临床疗效，可能与提高患者血清SOD，降低MDA有关。 【关键词】 斜视康泰方 麻痹性斜视 超氧化物歧化酶 丙二醛 　　Abstract：ObjectiveTo investigate the effect of Xieshikangtaifang on the change of superoxide dismutase and malondialdehyde in paralytic trabismus patients. Methods80 patients were randomly divided into two groups. The control group (n=40) was treated with routine Western medicine. Xieshikangtaifang was given to the therapy group (n=40) in addition to routine Western medicine. The therapeutic effect was evaluated after 4 weeks of treatment. Peripheral blood was taken from every patient before and after treatment to detect the levels of SOD and MDA in serum. ResultsBefore treatment,the level of SOD in serum in paretic strabismus patients was at the low level of normal range,the level of MDA was higher than normal value. After treatment Xieshikangtaifang elevated the level of SOD and reduced the level of MDA in serum. The therapy group showed a higher effective rate and better improving of main symptom than control group (Plt;0.05). ConclusionXieshikangtaifang may be effective in the treatment of paralytic strabismus and its therapeutic effect may be correlated with the increase of SOD activity and the decrease of MDA level in serum. 　　Key words：Xieshikangtaifang； Paralytic strabismus； SOD； MDA 　　麻痹性斜视(paralytic strabismus)是以一条或数条眼外肌完全或不完全麻痹而引起的眼位偏斜，眼球运动受限，复视，眩晕，恶心呕吐等为特征的眼病。为眼科临床常见病，多为一眼发病，起病突然，患者往往因严重的自觉症状而影响工作及生活［1］，属“风牵偏视”“视歧”“目偏视”“视一为二症”“睑废”等范畴。本研究于200103～200602观察了40例患者血清超氧化物歧化酶（SOD），丙二醛（MDA）的变化以及斜视康泰方对其的影响。现报道如下。 　　1 对象和方法 　　1.1 临床资料 　　本研究对象80例患者共分两组，用随机数字表法随机分组，信封法随机隐藏。①斜视康泰方组40例 ， 其中男28例，女12例；年龄最大65岁，最小5岁，平均年龄42.7岁；病程最长4年，最短7 d，平均30.5 d；上直肌麻痹6例，下直肌麻痹3例，内直肌麻痹6例，外直肌麻痹20例，上斜肌麻痹1例，动眼神经麻痹4例；右眼26例，左眼14例；病因为糖尿病