强效抗逆转录治疗对艾滋病患者CD+4T淋巴细胞动态影响.docVIP

强效抗逆转录治疗对艾滋病患者CD+4T淋巴细胞动态影响 　【摘要】 目的 观察强效抗逆转录治疗对艾滋病患者CD+4T淋巴细胞的动态影响。方法 分析25例患者在治疗前（DO）和抗逆转录病毒（HAART）治疗第3、6、12个月时外周血中CD+4T淋巴细胞、CD+4T淋巴细胞百分率的动态变化。结果 AIDS患者组与正常对照组CD+4T淋巴细胞、CD+4T淋巴细胞百分率指标间差异存在非常显著性（t=24.98、t=11.61，P均＜0.001）。25例患者DO前根据CD4+T淋巴细胞数量分为Ⅰ组（＜100个／μL）、Ⅱ组（100～200个／μL）、Ⅲ组（＞200个／μL），经3、6、12个月HAART 治疗后CD+4T淋巴细胞、CD+4T淋巴细胞百分率指标均有不同程度提高，各组与DO前比较:Ⅰ组P均＜0.01、Ⅱ组CD+4T淋巴细胞P＜0.05、CD+4T淋巴细胞百分率指标P＞0.05、 Ⅲ组P均＞0.05。Ⅰ组DO前CD+4T淋巴细胞、CD+4T淋巴细胞百分率指标最低，经12个月治疗后CD+4T淋巴细胞、CD+4T淋巴细胞百分率指标增加最为明显。有关CD+4T淋巴细胞绝对数的增加比较：Ⅰ组与Ⅱ组、Ⅲ组比较，P均＜0.01；Ⅱ组与Ⅲ组比较，P＞0.05。结论 HAART能有效回升AIDS患者CD+4T淋巴细胞数量，提示HAART治疗对CD+4T淋巴细胞数量越低患者疗效越为显著。 丁国祥（1960～），男，回族，河南籍，主管技师 【关键词】 人免疫缺陷病毒 艾滋病患者 CD+4T淋巴细胞 强效抗逆转录病毒治疗 流式细胞技术 Abstract Objective To investigate the dynamic changes of AIDS patients CD4+ T cell absolute quantity and percentage with HAART continuously to suppress effectively HIV replication process. Methods Totally 25 AIDS patients were included .During HAART (including DO, M3 ,M6 ,M12), the number of CD4+ T cell absolute quantity and CD4+ T cell percentage in AIDS patients blood were detected with FCM. Results There are very quite difference in the CD4+ T cell number and percentage of AIDS patients group and the normal control group （t=24.98、t=11.61、P＜0.001）. 25 patients were classified into three groups according to the CD4+ T cell quantity on DO: group I (lt; 100/ μL), group II (100 ～200/μL), group III (gt; 200/ μL). After the initiation of M3, M6, M12 HAART, including the CD4+ T cell counts and percentages of CD4+ T cell in these patients were improved gradually, each group was compared with DO: group I(P lt;0.01),group II CD4+ T cell (P lt; 0.05), CD4+ T percentages( P＞0.05),group III (P ＞0.05). After 12 months treatments, the improvement response in group I was most remarkable even with the lowest CD4+ T cell count and the CD4+ T cell percentage on DO. group I compares with group II and III (P lt; 0.01), group II compares with III group (P ＞ 0.05). Conclusion It is suggested that the levels of AIDS patients CD4+