the potential contribution of mass treatment to the control of plasmodium falciparum malaria大规模治疗的潜在贡献的控制恶性疟原虫疟疾.pdfVIP

The Potential Contribution of Mass Treatment to the Control of Plasmodium falciparum Malaria 1 1 2 ´ 1 1 Lucy C. Okell *, Jamie T. Griffin , Immo Kleinschmidt , T. Deirdre Hollingsworth , Thomas S. Churcher , 1 3 3 1 Michael J. White , Teun Bousema , Chris J. Drakeley , Azra C. Ghani 1 Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modeling, Imperial College London, London, United Kingdom, 2 Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3 Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom Abstract Mass treatment as a means to reducing P. falciparum malaria transmission was used during the first global malaria eradication campaign and is increasingly being considered for current control programmes. We used a previously developed mathematical transmission model to explore both the short and long-term impact of possible mass treatment strategies in different scenarios of endemic transmission. Mass treatment is predicted to provide a longer-term benefit in areas with lower malaria transmission, with reduced transmission levels for at least 2 years after mass treatment is ended in a scenario where the baseline slide-prevalence is 5%, compared to less than one year in a scenario with baseline slide- prevalence at 50%. However, repeated annual mass treatment at 80% coverage could achieve around 25% reduction in infectious bites in moderate-to-high transmission settings if sustained. Using vector co