the public health utility of genome-wide association study results for smoking behavior全基因组关联研究结果的公共卫生效用的吸烟行为.pdfVIP

Furberg et al. Genome Medicine 2010, 2:26 /content/2/4/26 CO M M E N TA R Y The public health utility of genome-wide association study results for smoking behavior 1,2 1 3 2 Helena Furberg* , Jamie Ostro , Caryn Lerman and Patrick F Sullivan GWASs of smoking behavior Abstract Since 2007, several GWASs among individuals of Euro- New approaches to improve smoking cessation rates pean ancestry have been conducted for different smoking are needed. In recent years, substantial progress has phenotypes, including smoking initiation (ever versus been made in understanding the genetics of smoking never smokers), age of smoking initiation, number of behavior, and this knowledge may eventually be cigarettes smoked per day (CPD), nicotine dependence used to personalize treatment for smokers. Although (based on the Fagerström test for nicotine dependence there are highly signicant and reproducible genetic score), smoking cessation (former versus current smokers), associations, none are yet ready for clinical applications. pack-years and duration of smoking (see Supplementary We suggest that translational research from several Table  1 in [2]). Most recently, meta-analyses were con- disciplines, including behavioral science, ethics and ducted among 143,023 individuals of European ancestry economics, should be performed in parallel with [2-4]. Remarkably, whereas p