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the relationship between attention deficit hyperactivity disorder and premature infants in taiwanese a case control study注意缺陷多动障碍之间的关系和早产儿在台湾一个病例对照研究
Chu et al. BMC Psychiatry 2012, 12:85
/1471-244X/12/85
RESEARCH ARTICLE Open Access
The relationship between attention deficit
hyperactivity disorder and premature infants in
Taiwanese: a case control study
1,5 3,6 2 1,5 1,5
Shih-Ming Chu , Ming-Horng Tsai , Fan-Ming Hwang , Jen-Fu Hsu , Hsuan Rong Huang
and Yu-Shu Huang4,5,7*
Abstract
Background: Preterm survivors from the neonatal intensive care unit (NICU) are considered to be at risk for some
neurobehavioral disorders such as attention-deficit/hyperactivity disorder (ADHD). The current study aimed to
explore the relationship between ADHD and premature infants in Taiwan.
Methods: A total of 195 children (157 males and 38 females) diagnosed with ADHD based on DSM-IV and aged
between 6 to 12 years and a control group of 212 (164 males, 48 females) age- and sex-matched healthy children
were enrolled. The ADHD-Rating scale and CGI severity were performed by child psychiatrists. Demographic data of
the children, including birth history, perinatal neurological and respiratory problems were collected to facilitate the
investigation of whether a correlation exists between ADHD and prematurity.
Results: The ADHD group had a significantly higher rate of prematurity and significantly higher rate of low birth
body weight (defined as 2500 g) than the control group (both P = 0.003). Pearson correlation showed a
significantly negative correlation between gestational age and ADHD-RS score, inattentive score, hyperactivity and
CGI-S score (P = 0.004, 0.013, 0.015 and 0.002, respectively). However, only a CGI-S score (P = 0.018) showed a
significantly correlation between low birth weight and ADHD.
Conclusions: Premature infants have significantly more seve
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