the place for short-acting opioids special emphasis on remifentanil短效阿片类药物的地方特别强调remifentanil.pdfVIP

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the place for short-acting opioids special emphasis on remifentanil短效阿片类药物的地方特别强调remifentanil.pdf

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the place for short-acting opioids special emphasis on remifentanil短效阿片类药物的地方特别强调remifentanil

Available online /content/12/S3/S5 Review The place for short-acting opioids: special emphasis on remifentanil Wolfram Wilhelm1 and Sascha Kreuer2 1Department of Anesthesiology and Intensive Care Medicine, Klinikum St.-Marien-Hospital Lünen, 44534 Lünen, Altstadtstrasse, Germany 2Department of Anesthesiology, Intensive Care and Pain Medicine, University of Saarland, 66421 Homburg/Saar, Kirrberger Strasse, Germany Corresponding author: Wolfram Wilhelm, wolfram.wilhelm@smh-online.de Published: 14 May 2008 Critical Care 2008, 12(Suppl 3):S5 (doi:10.1186/cc6152) This article is online at /content/12/S3/S5 © 2008 BioMed Central Ltd Abstract of pain medication, and opioids are most frequently adminis- Pain is among the worst possible experiences for the critically ill. tered in this setting. Some years ago, a European investi- Therefore, nearly all intensive care patients receive some kind of gation into analgesia and sedation in the ICU [2] revealed pain relief, and opioids are most frequently administered. Morphine that the drugs most commonly used for analgesia were has a number of important adverse effects, including histamine morphine (33%), fentanyl (33%), and sufentanil (24%), and release, pruritus, constipation, and, in particular, accumulation of also demonstrated substantial differences in analgesic morphine-6-glucuronide in patients with renal impairment. Hence, it practice throughout Europe. is not an ideal analgesic for use in critically