the relationship between proteome size, structural disorder and organism complexity蛋白质组的大小之间的关系,结构紊乱和生物体的复杂性.pdfVIP
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the relationship between proteome size, structural disorder and organism complexity蛋白质组的大小之间的关系,结构紊乱和生物体的复杂性
Schad et al. Genome Biology 2011, 12:R120
/2012/12/12/R120
RESEARCH Open Access
The relationship between proteome size,
structural disorder and organism complexity
*
Eva Schad, Peter Tompa and Hedi Hegyi
Abstract
Background: Sequencing the genomes of the first few eukaryotes created the impression that gene number
shows no correlation with organism complexity, often referred to as the G-value paradox. Several attempts have
previously been made to resolve this paradox, citing multifunctionality of proteins, alternative splicing, microRNAs
or non-coding DNA. As intrinsic protein disorder has been linked with complex responses to environmental stimuli
and communication between cells, an additional possibility is that structural disorder may effectively increase the
complexity of species.
Results: We revisited the G-value paradox by analyzing many new proteomes whose complexity measured with
their number of distinct cell types is known. We found that complexity and proteome size measured by the total
number of amino acids correlate significantly and have a power function relationship. We systematically analyzed
numerous other features in relation to complexity in several organisms and tissues and found: the fraction of
protein structural disorder increases significantly between prokaryotes and eukaryotes but does not further increase
over the course of evolution; the number of predicted binding sites in disordered regions in a proteome increases
with complexity; the fraction of protein disorder, predicted binding sites, alternative splicing and protein-protein
interactions all increase with the complexity of human tissues.
Conclusions: We conclude that complexity is a multi-parametric trait, determined by interaction potential,
alternative splicing capacit
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