the pore-forming toxin β hemolysincytolysin triggers p38 mapk-dependent il-10 production in macrophages and inhibits innate immunity成孔毒素βhemolysincytolysin触发p38 mapk-dependent il - 10在巨噬细胞,抑制生产先天免疫.pdfVIP

the pore-forming toxin β hemolysincytolysin triggers p38 mapk-dependent il-10 production in macrophages and inhibits innate immunity成孔毒素βhemolysincytolysin触发p38 mapk-dependent il - 10在巨噬细胞,抑制生产先天免疫.pdf

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the pore-forming toxin β hemolysincytolysin triggers p38 mapk-dependent il-10 production in macrophages and inhibits innate immunity成孔毒素βhemolysincytolysin触发p38 mapk-dependent il - 10在巨噬细胞,抑制生产先天免疫

The Pore-Forming Toxin b hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity 1,2,3 4 1,2,3 5¤ 5 6 Magali Bebien , Mary E. Hensler , Suzel Davanture , Li-Chung Hsu , Michael Karin , Jin Mo Park , 1,2,3 7 4 1,2,3 Lena Alexopoulou , George Y. Liu , Victor Nizet , Toby Lawrence * ´ ´ 1 Centre d’Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, 2 Institut National de la Sante et de la Recherche Medicale (INSERM), U1104, Marseille, France, 3 Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France, 4 Department of Pediatrics and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, School of Medicine, La Jolla, California, United States of America, 5 Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California, United States of America, 6 Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, 7 Immunobiology Institute, Cedars-Sinai Medical Center, University of California Los Angeles, School of Medicine, Los Angeles, California, United States of America Abstract Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns and immune- compromised adults. The pore-forming toxin (PFT) b hemolysin/cyto

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