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the relationships between biological activities and structure of flavan-3-olsflavan-3-ols的生物活性和结构之间的关系.pdf

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the relationships between biological activities and structure of flavan-3-olsflavan-3-ols的生物活性和结构之间的关系

Int. J. Mol. Sci. 2011, 12, 9342-9353; doi: 10.3390/ijms12 129342 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article The Relationships Between Biological Activities and Structure of Flavan-3-Ols Cornelia Braicu 1, Valentina Pilecki 2, Ovidiu Balacescu 1, Alexandru Irimie 3,4 and Ioana Berindan Neagoe 1,5,* 1 Department of Functional Genomics and Experimental Pathology, Cancer Institute “Ion Chiricuta”, 34-35 Republicii, Cluj-Napoca 400015, Romania; E-Mails: cornelia.braicu@iocn.ro (C.B.); ovidiubalacescu@iocn.ro (O.B.) 2 Faculty of Biology and Geology, Babes-Bolyai University, 44 Gheorghe Bilascu, Cluj-Napoca 4000006, Romania; E-Mail: valentinapilecki@ 3 Department of Surgical Oncology, University of Medicine and Pharmacy, “Iuliu Hatieganu”, 8 Victor Babes, Cluj-Napoca 400427, Romania; E-Mail: airimie@umfcluj.ro 4 Department of Surgery, Cancer Institute “Ion Chiricuta”, 34-35 Republicii, Cluj-Napoca 400015, Romania 5 Department of Immunology, University of Medicine and Pharmacy “Iuliu Hatieganu”, 8 Victor Babes, Cluj-Napoca 400427, Romania * Author to whom correspondence should be addressed; E-Mail: ioanaberi@iocn.ro; Tel.: +40-264-450749; Fax: +40-264-598885. Received: 27 October 2011; in revised form: 23 November 2011 / Accepted: 5 December 2011 / Published: 13 December 2011 Abstract: Flavan-3-ols are involved in multiple metabolic pathways that induce inhibition of cell proliferation. We studied the structure-activity relationship of gallic aci