the potential role of cannabinoids in modulating serotonergic signaling by their influence on tryptophan metabolism大麻类的潜在作用调节血清素激活的信号对色氨酸代谢的影响.pdfVIP
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the potential role of cannabinoids in modulating serotonergic signaling by their influence on tryptophan metabolism大麻类的潜在作用调节血清素激活的信号对色氨酸代谢的影响
Pharmaceuticals 2010, 3, 2647-2660; doi:10.3390/ph3082647
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Potential Role of Cannabinoids in Modulating Serotonergic
Signaling by Their Influence on Tryptophan Metabolism
Marcel Jenny 1, Sebastian Schröcksnadel 2, Florian Überall 1 and Dietmar Fuchs 2,*
1 Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
2 Division of Biological Chemistry, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
* Author to whom correspondence should be adressed; E-Mail: dietmar.fuchs@i-med.ac.at;
Tel.: +43-512-9003-70350; Fax: +43-512-9003-73330.
Received: 13 July 2010; in revised form: 6 August 2010/ Accepted: 11 August 2010 /
Published: 13 August 2010
Abstract: Phytocannabinoids present in Cannabis plants are well known to exert potent
anti-inflammatory and immunomodulatory effects. Previously, we have demonstrated that
the psychoactive Δ9-tetrahydrocannabinol (THC) and the non-psychotropic cannabidiol
(CBD) modulate mitogen-induced Th1-type immune responses in peripheral blood
mononuclear cells (PBMC). The suppressive effect of both cannabinoids on mitogen-
induced tryptophan degradation mediated by indoleamine-2,3-dioxygenase (IDO), suggests
an additional mechanism by which antidepressive effects of cannabinoids might be linked
to the serotonergic system. Here, we will review the role of tryptophan metabolism in the
course of cell mediated immune responses and the
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