原创力文档the role of b-cells and igm antibodies in parasitemia, anemia, and vsg switching in trypanosoma brucei–infected miceb细胞的作用,igm抗体寄生虫血症、贫血,vsg切换在锥虫属brucei-infected老鼠.pdfVIP
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the role of b-cells and igm antibodies in parasitemia, anemia, and vsg switching in trypanosoma brucei–infected miceb细胞的作用,igm抗体寄生虫血症、贫血,vsg切换在锥虫属brucei-infected老鼠
The Role of B-cells and IgM Antibodies in Parasitemia,
Anemia, and VSG Switching in Trypanosoma brucei –
Infected Mice
1,2,3 1 1 4 1,2
Stefan Magez , Anita Schwegmann , Robert Atkinson , Filip Claes , Michael Drennan , Patrick De
2,3 1
Baetselier , Frank Brombacher *
1 Division of Immunology, Institute for Infectious Diseases and Molecular Medicine (IIDMM), Health Science Faculty, University of Cape Town, and International Centre for
Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa, 2 Department of Molecular and Cellular Recognition, VIB, Brussels, Belgium, 3 Laboratory of
Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium, 4 Laboratory of Serology, Institute for Tropical Medicine ‘‘Prins Leopold’’,
Antwerpen, Belgium
Abstract
African trypanosomes are extracellular parasitic protozoa, predominantly transmitted by the bite of the haematophagic
tsetse fly. The main mechanism considered to mediate parasitemia control in a mammalian host is the continuous
interaction between antibodies and the parasite surface, covered by variant-specific surface glycoproteins. Early
experimental studies have shown that B-cell responses can be strongly protective but are limited by their VSG-specificity.
We have used B-cell (mMT) and IgM-deficient (IgM2/ 2) mice to investigate the role of B-cells and IgM antibodies in
parasitemia control and the in vivo induction of trypanosomiasis-associated anemia. These infection studies revealed that
that the initial setting of peak levels of parasitemia in Trypanosoma
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