原创力文档the role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritisanti-α-actinin抗体的作用在狼疮肾炎的发病机制和监控.pdfVIP
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the role of anti-α-actinin antibodies in the pathogenesis and monitoring of lupus nephritisanti-α-actinin抗体的作用在狼疮肾炎的发病机制和监控
Available online /content/11/6/137
Editorial
The role of anti-αα-actinin antibodies in the pathogenesis and
monitoring of lupus nephritis
Pierre Youinou1 and Chaim Putterman2,3
1Laboratory of Immunology, Brest University Medical School Hospital, 2 Avenue Foch, BP924, F29609, Brest, France
2Division of Rheumatology, Albert Einstein College of Medicine, Forchheimer 701N, 1300 Morris Park Avenue, Bronx, NY 10461, USA
3Department of Microbiology and Immunology, Albert Einstein College of Medicine, Forchheimer 701N, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Corresponding author: Chaim Putterman, chaim.putterman@
Published: 11 December 2009 Arthritis Research Therapy 2009, 11:137 (doi:10.1186/ar2869)
This article is online at /content/11/6/137
© 2009 BioMed Central Ltd
See related research by Manson et al., /content/11/5/R154
Abstract suppressives, many patients fail to enter into remission, while
Antibodies to double-stranded DNA are important in the drug regimens used today can be associated with serious
pathogenesis of nephritis, a major clinical manifestation in lupus side effects or poor patient tolerance or both [2]. Assuming
patients. Since earlier diagnosis of renal involvement may lead to that earlier diagnosis of LN is associated with better
better outcomes, identification of the nephritogenic specificity of outcomes, investigators are undertaking major efforts to
lupus-associated autoantibodies is important in understanding the identify serologic markers to assist in diagnosis and follow-up
disease, while monitoring their titer clinically may serve
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