原创力文档the role of carvedilol in the treatment of dilated and anthracyclines-induced cardiomyopathy卡维地洛治疗作用的扩张和anthracyclines-induced心肌病.pdfVIP
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the role of carvedilol in the treatment of dilated and anthracyclines-induced cardiomyopathy卡维地洛治疗作用的扩张和anthracyclines-induced心肌病
Pharmaceuticals 2011, 4, 770-781; doi:10.3390/ph4050770
OPEN ACCESS
Pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Role of Carvedilol in the Treatment of Dilated and
Anthracyclines-Induced Cardiomyopathy
Kenichi Watanabe 1,*, Wawaimuli Arozal 1,2, Flori R. Sari 1,3, Somasundaram Arumugam 1,
1 4 5
Rajarajan A. Thandavarayan , Kenji Suzuki and Makoto Kodama
1 Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of
Pharmacy and Applied Life Sciences, Niigata City 956-8603, Japan
2 Department of Pharmacology, Faculty of Medicine, University of Indonesia, Jakarta 10430,
Indonesia
3 Department of Pharmacology, Faculty of Medicine and Health Sciences, Syarif Hidayatullah
Jakarta, State Islamic University, South Jakarta 15412, Indonesia
4 Department of Gastroenterology and Hepatology, Niigata University Graduate School of Medical
and Dental Sciences, Niigata City 951-8510, Japan
5 First Department of Internal Medicine, Niigata University Graduate School of Medical and Dental
Science, Niigata City 951-8510, Japan
* Author to whom correspondence should be addressed; E-Mail: watanabe@nupals.ac.jp;
Tel.: +81-250-25-5267; Fax: +81-250-25-5021.
Received: 4 March 2011; in revised form: 11 May 2011 / Accepted: 19 May 2011 /
Published: 24 May 2011
Abstract: Although chronic sympathetic activation provides inotropic and chronotropic
support to the failing heart, such activation may also have deleterious effects, i
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