原创力文档the role of cardiac troponin t quantity and function in cardiac development and dilated cardiomyopathy心肌肌钙蛋白t的角色数量和功能开发和扩张型心肌病心脏.pdfVIP
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the role of cardiac troponin t quantity and function in cardiac development and dilated cardiomyopathy心肌肌钙蛋白t的角色数量和功能开发和扩张型心肌病心脏
The Role of Cardiac Troponin T Quantity and Function in
Cardiac Development and Dilated Cardiomyopathy
1,2,3 1 1 1 4
Ferhaan Ahmad *, Sanjay K. Banerjee , Michele L. Lage , Xueyin N. Huang , Stephen H. Smith , Samir
1 1 3 4 5 5
Saba , Jennifer Rager , David A. Conner , Andrzej M. Janczewski , Kimimasa Tobita , Joseph P. Tinney ,
6 6 5 1
Ivan P. Moskowitz , Antonio R. Perez-Atayde , Bradley B. Keller , Michael A. Mathier , Sanjeev G.
4 3 3
Shroff , Christine E. Seidman , J. G. Seidman
1 Cardiovascular Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Department of Human Genetics,
University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 Department of Genetics, Howard Hughes Medical Institute and Harvard Medical School,
Boston, Massachusetts, United States of America, 4 Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America,
5 Department of Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 6 Department of Pathology,
Children’s Hospital, Boston, Massachusetts, United States of America
Abstract
Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies result from sarcomeric protein mutations, including
cardiac troponin T (cTnT, TNNT2). We determined whether TNNT2 mutations cause cardi
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