the role of colorectal cancer stem cells in metastatic disease and therapeutic response结直肠癌干细胞的作用在转移性疾病和治疗反应.pdfVIP

Cancers 2011, 3, 319-339; doi:10.3390/cancers3010319 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review The Role of Colorectal Cancer Stem Cells in Metastatic Disease and Therapeutic Response 1 2 3 4 Eric C. Anderson , Crystal Hessman , Trevor G. Levin , Marcus M. Monroe and Melissa H. Wong 5,* 1 Division of Hematology/Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; E-Mail: andeeric@ 2 Department of Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; E-Mail: hessmanc@ 3 Department of Cell and Developmental Biology, Knight Cancer Institute, Oregon Stem Cell Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; E-Mail: levint@ 4 Department of Otolaryngology—Head and Neck Surgery, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA; E-Mail: monroem@ 5 Department of Dermatology, Department of Cell and Developmental Biology, Knight Cancer Institute, Oregon Stem Cell Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA * Author to whom correspondence should be addressed; E-Mail: wongme@; Tel.: +1 (503) 494-8749; Fax: +1 (503) 418-4266. Received: 1 December 2010; in revised form: 17 December 2010 / Accepted: 10 January 2011 / Published: 14 January 2011 Abstract: Colorectal cancer is the thir