原创力文档the role of cytokines and hot flashes in perimenopausal depression细胞因子的作用,在抑郁症的围绝经期潮热.pdfVIP
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the role of cytokines and hot flashes in perimenopausal depression细胞因子的作用,在抑郁症的围绝经期潮热
Karaoulanis et al. Annals of General Psychiatry 2012, 11:9
/content/11/1/9
PRIMARY RESEARCH Open Access
The role of cytokines and hot flashes in
perimenopausal depression
1* 2 3 4 2
Sokratis E Karaoulanis , Alexandros Daponte , Katerina A Rizouli , Andreas A Rizoulis , Georgios A Lialios ,
Catherine T Theodoridou3, Christos Christakopoulos5 and Nikiforos V Angelopoulos1
Abstract
Background: An imbalance in the production of proinflammatory and anti-inflammatory cytokines may play a role
in the pathophysiology of perimenopausal depression. The aim of this study was to examine serum levels of the
proinflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor a (TNFa), and the anti-inflammatory
cytokine IL-10, in perimenopausal women suffering from depression. Furthermore, to assess whether serum
cytokine levels are associated with the presence of hot flashes or the use of selective serotonin reuptake inhibitors
(SSRIs). We also evaluated the possible association of hot flashes and perimenopausal depression.
Methods: Serum samples from 65 perimenopausal women, 41 with depression and 24 without depression, were
assessed for serum IL-6, TNFa and IL-10 by conventional enzyme-linked immunosorbent assays. Depression was
evaluated by the 17-item Hamilton Depression Rating Scale (HAM-D 17) and a psychiatric interview. The presence
and severity of hot flashes were examined using the Menopause Rating Scale (MRS).
Results: Serum levels cytokines did not differ between depressed women and normal controls. Serum levels of
cytokines did not change significantly in depressed women with hot flashes or in depressed women treated with
SSRIs. Hot flashes were strongly associated (P 0.0001) with perime
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