原创力文档the role of cannabinoid receptors in the descending modulation of pain大麻素受体的作用在下行调制的疼痛.pdfVIP
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the role of cannabinoid receptors in the descending modulation of pain大麻素受体的作用在下行调制的疼痛
Pharmaceuticals 2010, 3, 2661-2673; doi:10.3390/ph3082661
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Role of Cannabinoid Receptors in the Descending
Modulation of Pain
Enza Palazzo *, Livio Luongo, Vito de Novellis, Francesco Rossi and Sabatino Maione
Department of Experimental Medicine, Pharmacological Division, the Second University of Naples,
via Costantinopoli 16, 80138 Naples, Italy; E-Mails: livioluongo@inwind.it (L.L.);
vito.denovellis@unina2.it (V.D.N.); francesco.rossi@unina2.it (F.R.); sabatino.maione@unina2.it (S.M.)
* Author to whom correspondence should be addressed; E-Mail: enza.palazzo@unina2.it;
Tel.: +39-(0)81-5665880; Fax: +39-(0)81-5667503.
Received: 28 June 2010; in revised form: 30 July 2010 / Accepted: 16 August 2010 /
Published: 16 August 2010
Abstract: The endogenous antinociceptive descending pathway represents a circuitry of
the supraspinal central nervous system whose task is to counteract pain. It includes the
periaqueductal grey (PAG)-rostral ventromedial medulla (RVM)-dorsal horn (DH) axis,
which is the best characterized pain modulation system through which pain is
endogenously inhibited. Thus, an alternative rational strategy for silencing pain is the
activation of this anatomical substrate. Evidence of the involvement of cannabinoid
receptors (CB) in the supraspinal modulation of pain can be found in several studies in
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