原创力文档the quiescent cellular state is arfp53-dependent and associated with h2ax downregulation and genome stability静止细胞状态和差别与h2ax arfp53-dependent和相关对这些基因组的稳定性.pdfVIP
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the quiescent cellular state is arfp53-dependent and associated with h2ax downregulation and genome stability静止细胞状态和差别与h2ax arfp53-dependent和相关对这些基因组的稳定性
Int. J. Mol. Sci. 2012, 13, 6492-6506; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
The Quiescent Cellular State is Arf/p53-Dependent and
Associated with H2AX Downregulation and Genome Stability
Ken-ichi Yoshioka 1,*, Yuko Atsumi 1,2, Hirokazu Fukuda 3, Mitsuko Masutani 1 and
4
Hirobumi Teraoka
1 Division of Genome Stability Research, National Cancer Center Research Institute, 5-1-1 Tsukiji,
Chuo-ku, Tokyo 104-0045, Japan; E-Mails: yuatsumi@ncc.go.jp (Y.A.);
mmasutan@ncc.go.jp (M.M.)
2 Department of Biosciences, School of Science, Kitasato University, 1-15-1 Kitasato, Minami-ku,
Sagamihara 228-8555, Japan
3 Division of Cancer Development System, National Cancer Center Research Institute, 5-1-1 Tsukiji,
Chuo-ku, Tokyo 104-0045, Japan; E-Mail: hfukuda@ncc.go.jp
4 Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental
University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan;
E-Mail: tera-pbc@tmd.ac.jp
* Author to whom correspondence should be addressed; E-Mail: kyoshiok@ncc.go.jp;
Tel.: +81-3-3542-2511; Fax: +81-3-3543-9305.
Received: 11 April 2012; in revised form: 21 May 2012 / Accepted: 22 May 2012 /
Published: 24 May 2012
Abstract: Cancer is a disease associated with genomic instability and mutations. Excluding
some tumors with specific chromosomal translocations, most cancers that develop at an
advance
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